Seeded
1: Saint-Étienne (FRA) 26.049
2: Maccabi Tel-Aviv (ISR) 20.225 or Kairat Almaty (KAZ)
3: Spartak Moskva (RUS) 19.216
4: Vorskla Poltava (UKR) 11.976
5: Dinamo Minsk (BLR) 10.000 or St Patrick's Athletic (IRL)

Unseeded
6: AEK Larnaca (CYP) 9.435 or Cliftonville (NIR)
7: AEK Athens (GRE) 7.940
8: Vojvodina (SRB) 7.925 or Connah's Quay (WAL)
9: Pandurii Târgu Jiu (ROU) 7.076
10: Lokomotiva Zagreb (CRO) 5.775 or RoPS Rovaniemi (FIN)

Group 2

Seeded
1: AZ Alkmaar (NED) 43.612
2: Krasnodar (RUS) 24.216
3: Partizan (SRB) 16.925 or Zagłebie Lubin (POL)
4: Sassuolo (ITA) 14.087
5: Rio Ave (POR) 13.616
6: Omonia (CYP) 9.935 or Beitar Jerusalem (ISR)

Unseeded
7: Slovan Bratislava (SVK) 8.900 or Jelgava (LVA)
8: Luzern (SUI) 8.775
9: Stromsgodset (NOR) 7.850 or SonderjyskE (DEN)
10: Slavia Praha (CZE) 6.585 or Levadia Tallinn (EST)
11: Hearts (SCO) 6.460 or Birkirkara (MLT),
12: Giannina (GRE) 5.940 or Odd (NOR)

Group 3

Seeded
1: Lille (FRA) 29.549
2: Maribor (SVN) 21.625 or Levski Sofia (BUL)
3: Austria Wien (AUT) 19.020 or Kukës (ALB)
4: Panathinaikos (GRE) 14.940
5: Maccabi Haifa (ISR) 11.725 or Nomme Kalju (EST)
6: Hajduk Split (CRO) 10.775 or laşi (ROU)

Unseeded
7: Oleksandriya (UKR) 8.976
8: AIK Solna (SWE) 8.975 or Europa (GIB)
9: Spartak Trnava (SVK) 7.400 or Shirak (ARM)
10: Osmanlispor* (TUR) 6.920 or Zimbru Chisinau (MDA)
11: Ventspils (LVA) 6.075 or Aberdeen (SCO)
12: Qäbälä (AZE) 5.225 or MTK Budapest (HUN)

Group 4

Seeded
1: Genk (BEL) 36.000 or Budućnost Podgorica (MNE)
2: Rapid Wien (AUT) 23.520
3: Hertha Berlin (GER) 16.035
4: Rijeka (CRO) 14.275
5: Arouca (POR) 10.616
6: Mladá Boleslav (CZE) 10.085

Unseeded
7: Neftçi PFK (AZE) 9.725 or Shkëndija (MKD)
8: Istanbul Başakşehir (TUR) 7.920
9: Brondby (DEN) 7.220 or Hibernian (SCO)
10: Heracles (NED) 7.112
11: Debrecen (HUN) 6.475 or Torpedo-Belaz Zhodino (BLR)
12: Häcken (SWE) 5.975 or Cork City (IRL)

Group 5

Seeded
1: Gent (BEL) 25.000
2: Slovan Liberec (CZE) 22.085
3: West Ham United (ENG) 16.256
4: Midtjylland (DEN) 14.720 or Vaduz (LIE)
5: HJK Helsinki (FIN) 10.980 or Beroe Stara Zagora (BUL)
6: Apollon Limassol (CYP) 10.435

Unseeded
7: Grasshoppers (SUI) 9.755 or KR Reykjavík (ISL)
8: Videoton (HUN) 8.725 or Čukarički (SRB)
9: Shakhtyor Soligorsk (BLR) 7.500 or Domžale (SVN)
10: IFK Göteborg (SWE) 6.475 or Piast Gliwice (POL)
11: Admira Wacker Mödling (AUT) 6.020 or Käpäz (AZE)
12: Viitorul Constanţa (ROU) 5.076

RoPS Rovaniemi (FIN)/Lokomotiva Zagreb (CRO) v Vorskla Poltava (UKR)
Saint-Étienne (FRA) v AEK Athens (GRE)
Cliftonville (NIR)/AEK Larnaca (CYP) v Spartak Moskva (RUS)
Pandurii Târgu Jiu (ROU) v Kairat Almaty (KAZ)/Maccabi Tel-Aviv (ISR)
Vojvodina (SRB)/Connah's Quay (WAL) v Dinamo Minsk (BLR)/St Patrick's Athletic (IRL)
Partizan (SRB)/Zagłebie Lubin (POL) v Stromsgodset (NOR)/SonderjyskE (DEN)
Austria Wien (AUT)/Kukës (ALB) v Shirak (ARM)/Spartak Trnava (SVK)
Hertha Berlin (GER) v Brondby (DEN)/Hibernian (SCO)
West Ham United (ENG) v Shakhtyor Soligorsk (BLR)/Domžale (SVN)
Luzern (SUI) v Sassuolo (ITA)
AIK Solna (SWE)/Europa (GIB) v Panathinaikos (GRE)
Istanbul Başakşehir (TUR) v Rijeka (CRO)
Videoton (HUN)/Čukarički (SRB) v Midtjylland (DEN)/Vaduz (LIE)
Levadia Tallinn (EST)/Slavia Praha (CZE) v Rio Ave (POR)
Zimbru Chisinau (MDA)/Osmanlispor* (TUR) v Maccabi Haifa (ISR)/Nomme Kalju (EST)
Heracles (NED) v Arouca (POR)
Piast Gliwice (POL)/IFK Göteborg (SWE) v Beroe Stara Zagora (BUL)/HJK Helsinki (FIN)
Birkirkara (MLT)/Hearts (SCO) v Krasnodar (RUS)
Aberdeen (SCO)/Ventspils (LVA) v Maribor (SVN)/Levski Sofia (BUL),
Debrecen (HUN)/Torpedo-Belaz Zhodino (BLR) v Rapid Wien (AUT)
Admira Wacker Mödling (AUT)/Käpäz (AZE)  v Slovan Liberec (CZE)
AZ Alkmaar (NED) v Giannina (GRE)/Odd (NOR)
Lille (FRA) v MTK Budapest (HUN)/Qäbälä (AZE)
Genk (BEL)/Budućnost Podgorica (MNE) v Häcken (SWE)/ Cork City (IRL)
Gent (BEL) v Viitorul Constanţa (ROU)
Slovan Bratislava (SVK)/Jelgava (LVA) v Omonia (CYP)/Beitar Jerusalem (ISR)
Oleksandriya (UKR) v laşi (ROU)/Hajduk Split (CRO)
Neftçi PFK (AZE)/Shkëndija (MKD) v Mladá Boleslav (CZE)
KR Reykjavík (ISL)/Grasshoppers (SUI) v Apollon Limassol (CYP)