1. kolo
2. kolo
| 04.09.2021. | Neretva | 3:0 | Junak | - |
| 04.09.2021. | Urania | 1:1 | Kamen | - |
| 04.09.2021. | Neretvanac | 2:2 | Zadar | - |
| 04.09.2021. | Zmaj Makarska | 1:1 | Uskok | - |
| 04.09.2021. | Split | 1:3 | Jadran Luka Ploče | - |
| 04.09.2021. | Hrvatski vitez | 2:1 | OSK Otok | - |
| 04.09.2021. | Sloga Mravince | 4:2 | Primorac Biograd | - |
| 04.09.2021. | Vodice | 1:1 | GOŠK Dubrovnik | - |
| 04.09.2021. | Hrvace | 2:0 | Zagora | - |
3. kolo
| 11.09.2021. | Zagora | 2:1 | Neretva | - |
| 11.09.2021. | GOŠK Dubrovnik | 0:0 | Hrvace | - |
| 11.09.2021. | Primorac Biograd | 5:0 | Vodice | - |
| 11.09.2021. | OSK Otok | 1:1 | Sloga Mravince | - |
| 11.09.2021. | Jadran Luka Ploče | 2:1 | Hrvatski vitez | - |
| 11.09.2021. | Uskok | 4:2 | Split | - |
| 11.09.2021. | Zadar | 0:1 | Zmaj Makarska | - |
| 11.09.2021. | Kamen | 1:1 | Neretvanac | - |
| 11.09.2021. | Junak | 4:0 | Urania | - |
4. kolo
| 14.09.2021. 17:00 | Neretva | 3:2 | Urania | - |
| 14.09.2021. 17:00 | Neretvanac | 2:0 | Junak | - |
| 14.09.2021. 17:00 | Zmaj Makarska | 0:2 | Kamen | - |
| 14.09.2021. 17:00 | Split | 1:1 | Zadar | - |
| 14.09.2021. 17:00 | Hrvatski vitez | 1:0 | Uskok | - |
| 14.09.2021. 17:00 | Sloga Mravince | 0:0 | Jadran Luka Ploče | - |
| 14.09.2021. 17:00 | Vodice | 1:1 | OSK Otok | - |
| 14.09.2021. 17:00 | Hrvace | 2:2 | Primorac Biograd | - |
| 14.09.2021. 17:00 | Zagora | 1:2 | GOŠK Dubrovnik | - |
6. kolo
| 25.09.2021. 16:00 | GOŠK Dubrovnik | 3:2 | Primorac Biograd | - |
| 25.09.2021. 16:00 | Hrvace | 2:0 | Jadran Luka Ploče | - |
| 25.09.2021. 16:00 | Hrvatski vitez | 3:0 | Kamen | - |
| 25.09.2021. 16:00 | Neretva | 1:2 | Neretvanac | - |
| 25.09.2021. 16:00 | Split | 1:0 | Junak | - |
| 25.09.2021. 16:00 | Vodice | 3:1 | Uskok | - |
| 25.09.2021. 16:00 | Zagora | 5:0 | OSK Otok | - |
| 25.09.2021. 16:00 | Zmaj Makarska | 2:0 | Urania | - |
| 26.09.2021. 16:00 | Sloga Mravince | 2:0 | Zadar | - |
8. kolo
| 02.10.2021. 15:30 | GOŠK Dubrovnik | -:- | Jadran Luka Ploče | - |
| 02.10.2021. 15:30 | Hrvace | -:- | Zadar | - |
| 02.10.2021. 15:30 | Hrvatski vitez | -:- | Urania | - |
| 02.10.2021. 15:30 | Neretva | -:- | Zmaj Makarska | - |
| 02.10.2021. 15:30 | Primorac Biograd | -:- | OSK Otok | - |
| 02.10.2021. 15:30 | Vodice | -:- | Kamen | - |
| 02.10.2021. 15:30 | Zagora | -:- | Uskok | - |
