| English Premiership |
|---|
| No. | Date | Ven | Opponent | Result | HT | Scorers | Attend |
|---|
| 1 | 13-Aug-05 | A | Everton | W | 2-0 | (1-0) | van Nistelrooy 43; W Rooney 46 | 38,610 |
| 2 | 20-Aug-05 | H | Aston Villa | W | 1-0 | (0-0) | van Nistelrooy 66 | 67,934 |
| 3 | 28-Aug-05 | A | Newcastle United | W | 2-0 | (0-0) | W Rooney 66; van Nistelrooy 90 | 52,327 |
| 4 | 10-Sep-05 | H | Manchester City | D | 1-1 | (1-0) | van Nistelrooy 45 | 67,839 |
| 5 | 18-Sep-05 | A | Liverpool | D | 0-0 | (0-0) |
| 44,917 |
| 6 | 24-Sep-05 | H | Blackburn Rovers | L | 1-2 | (0-1) | van Nistelrooy 67 | 67,765 |
| 7 | 01-Oct-05 | A | Fulham | W | 3-2 | (3-2) | van Nistelrooy 16p, 44; W Rooney 17 | 21,862 |
| 8 | 15-Oct-05 | A | Sunderland | W | 3-1 | (1-0) | W Rooney 39; van Nistelrooy 75; Giuseppe Rossi 86 | 39,085 |
| 9 | 22-Oct-05 | H | Tottenham Hotspur | D | 1-1 | (1-0) | Silvestre 6 | 67,856 |
| 10 | 29-Oct-05 | A | Middlesbrough | L | 1-4 | (0-3) | Ronaldo 90 | 30,579 |
| 11 | 06-Nov-05 | H | Chelsea | W | 1-0 | (1-0) | Fletcher 30 | 67,864 |
| 12 | 19-Nov-05 | A | Charlton Athletic | W | 3-1 | (1-0) | Smith 36; van Nistelrooy 69, 84 | 26,730 |
| 13 | 27-Nov-05 | A | West Ham United | W | 2-1 | (0-1) | W Rooney 46; O'Shea 55 | 34,755 |
| 14 | 03-Dec-05 | H | Portsmouth | W | 3-0 | (1-0) | Scholes 19; W Rooney 79; van Nistelrooy 83 | 67,684 |
| 15 | 11-Dec-05 | H | Everton | D | 1-1 | (1-1) | Giggs 14 | 67,831 |
| 16 | 14-Dec-05 | H | Wigan Athletic | W | 4-0 | (2-0) | Ferdinand 29; W Rooney 34, 54; van Nistelrooy 69p | 67,793 |
| 17 | 17-Dec-05 | A | Aston Villa | W | 2-0 | (1-0) | van Nistelrooy 9; Rooney 50 | 37,128 |
| 18 | 26-Dec-05 | H | West Bromwich Albion | W | 3-0 | (2-0) | Scholes 34; Ferdinand 45; van Nistelrooy 62 | 67,972 |
| 19 | 28-Dec-05 | A | Birmingham City | D | 2-2 | (1-1) | van Nistelrooy 4; Rooney 53 | 28,459 |
| 20 | 31-Dec-05 | H | Bolton Wanderers | W | 4-1 | (2-1) | N'Gotty(og) 7; Saha 43; Ronaldo 67, 90 | 67,858 |
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