Liga prvakinja, skupina A
9. kolo
| 08.01.2022. 16:00 | Ferencvaros | 26:22 | Budućnost | - |
| 08.01.2022. 16:00 | Rostov | 25:27 | Esbjerg | - |
| 09.01.2022. 14:00 | Podravka Vegeta | 24:32 | Borussia Dortmund | - |
10. kolo
| 29.01.2022. 16:00 | Esbjerg | 30:17 | Podravka Vegeta | Izvještaj |
| 29.01.2022. 20:00 | Brest Bretagne | 30:25 | Ferencvaros | - |
12. kolo
| 05.02.2022. 16:00 | Brest Bretagne | 31:25 | Borussia Dortmund | - |
| 05.02.2022. 16:00 | Ferencvaros | 25:25 | Rostov | - |
| 05.02.2022. 18:00 | Budućnost | 25:36 | Esbjerg | - |
| 06.02.2022. 16:00 | CSM Bukurešt | 29:21 | Podravka Vegeta | Izvještaj |
13. kolo
| 13.02.2022. 16:00 | Borussia Dortmund | -:- | Budućnost | - |
| 13.02.2022. 16:00 | Esbjerg | -:- | Brest Bretagne | - |
Liga prvakinja, skupina B
9. kolo
| 09.01.2022. 16:00 | Odense | 27:27 | CSKA Moskva | - |
| 09.01.2022. 16:00 | Sävehof | 23:42 | Vipers Kristiansand | - |
10. kolo
| 29.01.2022. 12:00 | Kastamonu | 26:29 | Sävehof | - |
11. kolo
| 09.02.2022. 18:45 | Metz Handball | -:- | Krim Mercator | - |
12. kolo
| 05.02.2022. 16:00 | Krim Mercator | 36:28 | Kastamonu | - |
| 05.02.2022. 18:00 | Vipers Kristiansand | 25:31 | Metz Handball | Izvještaj |
| 06.02.2022. 16:00 | CSKA Moskva | 23:27 | Györi | - |
| 06.02.2022. 16:00 | Odense | 37:24 | Sävehof | - |
13. kolo
| 12.02.2022. 16:00 | Vipers Kristiansand | 37:20 | Krim Mercator | - |
| 12.02.2022. 18:00 | Metz Handball | 38:31 | Odense | - |
| 13.02.2022. 14:00 | Kastamonu | -:- | CSKA Moskva | - |
| 13.02.2022. 16:00 | Sävehof | -:- | Györi | - |
